School of Medicine / Graduate School of Medicine / Graduate  School of Biomedical Science and Engineering / Faculty of  Medicine, Hokkaido University

Doctoral Dissertations 2017

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※ Students enrolled in April, 2007 or later

Degree conferred on March 23, 2017

Effect of left ventricular plication on wall stress and myocardial remodeling in a rat model of ischemic cardiomyopathy
Validation of cardiac progenitor cell therapy using mitochondrial drug delivery system for doxorubicin-induced cardiomyopathy
Plectin is a novel regulator for apical extrusion of RasV12-transformed cells
Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection
Study on the miR‐124/IQGAP1 signaling axis during EMT in endometrial cancer
Studies on the expression of lymphangiogenesis factor and the metastatic mechanism of malignant melanoma using an acquired lymphedema model in the mouse hindlimb
Studies on novel heterozygous mutation in coiled-coil domain of STAT1 in a patient with Mendelian susceptibility to mycobacterial diseases
Pathophysiological changes in platelet function and morphofunctional cardiac changes in pregnant women
Studies on relationship between bone quality and mechanical properties of cancellous bone
Studies in the synergistic effect of EZH2 inhibitor on chemoresistant ovarian cancer
The influence of childhood abuse and personality traits on depressive symptoms, idea of suicide and suicide attempts in individuals with schizophrenia
Functional analysis of caspase 3 gene regarding intervertebral disc degeneration using genetically modified mouse
Study of the effect of different neurorrhaphy on axonal regeneration in facial nerve reconstruction
Radiological study on CT and MRI in moyamoya disease
Feasibility study on a high performance PET device using multi-layer scintillation detector with novel pulse shape discrimination method
Diagnostic value of quantitative myocardial perfusion using dynamic 320-row multi-detector computed tomography in patients with coronary artery disease
Role of echocardiographic pulmonary regurgitant flow velocity analyses for the assessment of heart failure
Establishment of risk prediction models for estrogen receptor-positive breast cancer in Japanese women
Gene profiling for the personalized pathological diagnosis of diffuse-type gastric adenocarcinoma
Studies of real-time image gating on spot scanning proton therapy for lung cancer
Expression of the immunoproteasome subunit β5i in non-small cell lung cancers
Deterioration in distortion product otoacoustic emissions in auditory neuropathy patients with distinct clinical and genetic backgrounds
Effectiveness of the video-based home exercise on clinical and radiographic outcomes for subjects with osteoarthritis of the knee
Development of safe and efficient training system for laparoscopic inguinal hernia repair surgery
Long-term outcomes after the therapeutic ERCP using the balloon-assisted endoscopy for anastomotic stenosis of choledocho-jejunostomy or pancreatico-enterostomy
Pathogenesis of systemic lupus erythematosus
Studies on the pathogenicity of mutations in the C-terminal domain of keratin 1
Regulatory mechanisms of the innate immune response to virus infection and tumor
Analysis of CTL-dependent anti-tumor immune response induced by TLR3 adjuvant
Studies on regeneration therapy for central nervous system using bone marrow stromal cells
Ischemia-Induced small-conductance calcium-activated potassium channel activation deteriorates ventricular arrhythmias in cardiac hypertrophy through the CaMKII-dependent pathway
Studies on cognitive impairment assessed by COBRA in bipolar disorder
In vivo hypoxia imaging of brain tumors can visualize microscopic necrosis and anaerobic glycolysis
The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the nonclinical general adult population: Consideration by the hierarchical multiple regression analysis
Studies on long-term risk factors for atherothrombotic events in patients with acute coronary syndrome
Studies on the effects of antiosteoporosis agents on immobilization-associated osteoporosis in diffuse idiopathic skeletal hyperostosis
Diagnostic approach for the hereditary interstitial lung disease in childhood
The role of CD44-positive glomerular parietal epithelial cells in the mouse model of calcineurin inhibitor-induced nephrotoxicity
Regulation of intestinal microbial ecology system using Paneth-cell growth factor R-Spondin1 and antimicrobial peptides
Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy
Instrumental activities of daily livings (IADL) and depression in community-dwelling people aged 60 years or older in Kandy District, Sri Lanka - with special reference to ethnicity -
The development of a surgical technique for cartilage repair using an ultra-purified alginate gel
Studies on inhibition of alloreacitve T cells by PD-L1/PD-L2-expressing B-1 cells in mice
Studies on the relationship between neuroinflammation and synaptic plasticity in the mouse hippocampus
Chondrogenic differentiation of mouse induced pluripotent stem cells (iPSCs) and identification of differentiation biomarkers for the chondrogenic differentiation of iPSCs using glycomics monitoring
Studies on differences in perfusion between pharmacological stress and exercise stress on prone myocardial SPECT
Expression analysis of Wilms tumor 1 in esophageal, bile duct, pancreatic, and lung cancer
Studies on effects of V-ATPase inhibitor on cyst development of autosomal dominant polycystic kidney disease
Oral administration of conditioned medium obtained from mesenchymal stem cell culture prevents subsequent stricture formation after esophageal submucosal dissection in pigs
Studies on psychological and neurophysiological consequence of dietary habits and obesity
Therapeutic effects of human amnion-derived mesenchymal stem cell transplantation and conditioned medium enema in rats with trinitrobenzene sulfonic acid-induced colitis
Studies on the pathogenic mechanism of severe Wolfram syndrome which causes infantile diabetes mellitus
Studies on spot-scanning proton therapy in postoperative whole pelvic radiation therapy for gynecologic malignancies
Influence of psychosocial factor on symptoms of premenstrual dysphoric disorder
Studies on the usefulness of 18F­FDG PET/CT for assessing methotrexate­associated lymphoproliferative disorder (MTX-LPD)
A biomaterial study on development of double network hydrogel directly bondable to the bone and elucidation of the biological bonding mechanism