School of Medicine / Graduate School of Medicine / Graduate  School of Biomedical Science and Engineering / Faculty of  Medicine, Hokkaido University

Doctoral Dissertations 2016

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※ Students enrolled in April, 2007 or later

Degree conferred on December 26, 2016

A study of the diagnosis for portal venous invasion and the prognostic prediction of pancreatic head cancer

Degree conferred on September 26, 2016

Studies on near-infrared fluorescence imaging of thoracic duct in real time
Identification of a Highly Immunogenic Mouse Breast Cancer Sub Cell Line, 4T1-S
Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid
Analytical approach for efficient gating irradiation using three fiducial markers in a real-time tumor tracking system
Studies on the evaluation of sinus involvement and its related factors and biomarkers in asthmatics
Study of physiological functions of sphingomyelin and sphingomyelin synthase 2 by molecular imaging
Association of plasma amino acid concentrations with obesity and glucose metabolism in Japanese adults with normal glucose tolerance
Studies on development of new biomarker and therapeutics for pancreatic cancer targeting EphA4
Histochemical analysis of a hyarulonan receptor LYVE-1 in the reticulo-endothelial system

Degree conferred on June 30, 2016

Studies on Anti-inflammatory Effect of 3-[(dodecylthiocarbonyl) methyl]glutarimide on Murine Models of Inflammatory Bowel Disease
A feasibility study on real-time tumor tracking for radiation therapy, dynamic PET evaluation of the increased FLT uptake and optimization of helical acquisition parameters using multi pinhole collimator in Inveon SPECT
Molecular mechanism of interferon-gamma production in invariant natural killer T cells
Time-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan (CHP)-MAGE-A4
A study of the prognostic scoring system using preoperatively available factors to predict survival after surgical resection of perihilar cholangiocarcinoma
Studies on the Clinical Utility of Visualization of Collateral Channel with Coronary Computed Tomography Angiography
Development of digital/real hybrid phantoms and comparison of conventional ultrasonography and ultrasonography-computed tomography fusion imaging for target identification
p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex
Pathological analysis on vision threatening diseases complicated by proliferative tissue formation
Establishment of substrains from SFTSV YG1 strain selected by the degree of low pH dependent cell fusion activity and its application for serological diagnosis
Improvement of the Reproducibility of Parallel Transmission at 7T by Breath-Holding During the Calibration Scan
Evaluation of the biological effect of spot-scanning proton irradiation and studies on the sensitizing effect of 1-(3-C-Ethynyl-β-D-ribo-pentofuranosyl) cytosine for proton beam
Comparison between borderline ovarian tumors and carcinomas using semi-automated histogram analysis of diffusion-weighted imaging: focusing on solid components
Circulating NET levels in well-controlled type 2 diabetes and pathway involved in high-dose glucose-induced NET formation
Studies of molecular and genetic markers with clinicopathological features of meningeal tumors
Studies on Novel Application of Near-Infrared Fluorescence Imaging in Gastrointestinal Surgery

Degree conferred on March 24, 2016

Development of an in vitro long-term maintenance system of myeloid leukemia stem cells using human mesenchymal stromal cells
The Effect of Conservative Treatment and the Prospect of Union Status for Osteoporotic Vertebral Compression Fracture
Effect of human amnion-derived mesenchymal stem cell transplantation in rats with radiation proctitis
Analysis of biological response via viral RNA sensing pathway in HCV infection
Studies on the role of MicroRNA-296-3p in the malignant transformation and liquid biopsy for the metastasis in head and neck cancer
Studies on interaction between immune activating receptor DNAM-1 and CD155 in the development of acute graft-versus-host disease
Studies on the expression of intracellular protease in the thymus and thymic epithelial tumors
An exploration of the effects of unemployment experiences on the mental health of young people
A proposal of quality assurance procedures for a real-time tumor tracking radiotherapy system from the view point of imaging devices
Liver Elasticity Measurement Before and After Biliary Drainage in Patients With Obstructive Jaundice —A Prospective Cohort Study
CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing
Studies of neuroprotective effect of trans-arterial regional hypothermia on ischemic stroke
Studies on molecular basis of non-syndromic hypospadias: Systematic mutation screening and genome-wide copy-number analysis using next-generation sequencing and comparative genomic hybridization
Effect of Anesthetics Exposure on Emerging Granule Cells in Dentate Gyrus of Neonatal Rat
Development of treatment against cancer stem-like cells in esophageal squamous cell carcinoma by tyrosine kinase inhibitors
Studies for prevention of lymphedematous change and suppression of melanoma metastasis in lymphnode transplantation mouse model
Anti-lactoferrin antibodies contribute to enhancement of neutrophil extracellular trap formation and are associated with disease activity of eosinophilic granulomatosis with polyangiitis
Studies on mechanisms and treatment of secondary osteoporosis
Novel Large Cerebral Aneurysm Model Rat with Intraperitoneal Beta-AminoPropioNitril-Fumarate
Sterilization of the access port of CV catheters using povidone-iodine decreases incidence of catheter-associated bloodstream infection
The connection between mitochondria and keratin 5/14; Implications for epidermolysis bullosa simplex pathogenesis
Identification of plasma microRNA as a novel biomarker of sporadic amyotrophic lateral sclerosis
Effects of Ligament Remnant Tissue Preservation on the Tendon Graft after Anterior Cruciate Ligament Reconstruction: Biomechanical and Immunohistological Evaluations with A Sheep Model
The neurobiological basis of the antidepressant-like effect of exercise
The role of serotonergic mechanism in the rat prefrontal cortex for controlling the micturition reflex
Hepatitis B virus x protein impairs alpha interferon signaling through up-regulation of suppressor of cytokine signaling 3 and protein Phosphatase 2A
Studies of murine NK-triggering receptors expressed on myeloid cells and their response to Hepatitis B virus infection
Quantification of Vascular Function in Coronary and Brachial Arteries
Identification of novel diagnostic markers for malignant pleural mesothelioma by gene expression profiling analysis of an unique case
Mean kurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion kurtosis imaging
Extracellular cleavage of collagen XVII is essential for correct cutaneous basement membrane formation
Studies on c-Fos expression in area postrema of the rat induced by isoflurane
Comprehensive analysis of endothelial cells derived from moyamoya disease-specific induced pluripotent stem cells
Studies on the role of α-MSH-MC1R-MITF signaling pathway on TGF-β production in melanoma cells
A Multicenter Study of Strain/Strain rate versus Myocardial Velocity for Assessing Left Ventricular Relaxation and Filling Pressure: SMAP study
Studies on Four-Dimensional Computed Tomography for Improving Accuracy of Stereotactic Body Radiation Therapy using Real-time Tumor-tracking Radiotherapy System
mitoNEET regulates mitochondrial iron homeostasis
Circadian clock in the nasal mucosa: Analysis of clock gene expression rhythm to develop the chronotherapy for allergic rhinitis
The analysis of the glycosphingolipids functions in the articular cartilage repair
A study of the new preoperative prognostic scoring system to predict prognosis in patients with locally advanced pancreatic body cancer who undergo distal pancreatectomy with en bloc celiac axis resection
Studies on the relationships of left ventricular strain and strain rate to wall stress
Effect of maternal factors on sex differentiation in newborn infants
Studies on functional roles of glycosphingolipids in osteoarthritis and fracture healing process
Studies on the acceleration and axonal guidance ability of Neuregulin-1 in facial nerve regeneration
A functional analysis of CXCR7 expressed in tumor endothelial cells
The roles of AHR and IFI16 in antiviral innate immune response
Studies on effects of branched-chain amino acids and dietary protein loading on cyst development of autosomal dominant polycystic kidney disease
Elastgraphy Using Virtual Touch Quantification Method for Assessing Organ Congestion in Patients with Heart Failure
Studies on the Development of Systematic Training in Laparoscopic Surgery