School of Medicine / Graduate School of Medicine / Graduate  School of Biomedical Science and Engineering / Faculty of  Medicine, Hokkaido University

Doctoral Dissertations 2015

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※ Students enrolled in April, 2007 or later

Degree conferred on December 25, 2015

Preventive effects of statin on developing thrombosis in lupus patients with antiphospholipid antibodies and its mechanism

Degree conferred on September 25, 2015

Alteration of N-glycan Profiles in Diabetic Retinopathy
DHMEQ, a NF-κB inhibitor, prevents early islet graft damage by suppressing HMGB1 in murine pancreatic islet transplantation
Studies on the differentiation of myeloid cells under the chemotherapy-treated human pancreatic cancer microenvironment
Gait speed, daily walking and all-cause mortality in the younger-elderly Japanese: a cohort study
A study of the surgical treatment for intrahepatic cholangiocarcinoma focusing on lymph node metastasis
The epidemiological studies of the association between long working hours and health
Studies of machine perfusion preservation and pre-transplant graft therapy using siRNA in mouse liver transplantation model
TRIM29 regulates DNA repair and transcription
Functional analysis of a novel cardiac-specific protein RING finger protein 207
Studies on Immunosuppressive Effect of c-Fos/Activator Protein-1 Inhibition on Allogeneic Pancreatic Islet Transplantation

Degree conferred on June 30, 2015

Allorecognition by NK cells contribute to augmented hepatic ischemia/reperfusion injury with higher host neutrophil infiltration during early phase after liver transplantation
Studies of efficacies of 3-[(dodecylthiocarbonyl) methyl] glutarimide on graft arterial disease in mice.
Development of an enzyme-linked immunosorbent assay system based on recombinant leptospiral outer membrane protein LipL32 expressed by Escherichia coli and Pichia pastoris for Leptospira infection in rodents.
Studies on a mouse model for immunotherapy targeting cancer-associated antigen survivin 2B
Analysis of correlation between in vivo deposition of IgE autoantibodies in lesional skin and disease course in bullous pemphigoid.
Studies on the roles of the primate globus pallidus external segment in voluntary eye movements

Degree conferred on March 25, 2015

Mechanism of Acute Hemodynamic Effects Using Adaptive Servo-Ventilation in Patients with Heart Failure
A prospective randomized comparative study of endoscopic ultrasound-guided fine-needle aspiration between with and without the needle stylet using with the 22 gauge fine-needle aspiration needle
Biological basis of the anxiolytic-like effect of mirtazapine in the rat conditioned fear stress model
Growth inhibition of head and neck squamous carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing
Effects of Radiocontrast Agent and Local Anesthetic Agents on Intervertebral Disc Degeneration
Porphyrin Derivatives Mediated Sonodynamic Therapy on Malignant Glioma in Vitro
Studies on effective induction of cancer antigen-specific T cells and its application for cancer immunotherapy
Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats
Studies on functional regulation of human dendritic cells by IL-6/STAT3 signaling pathway and the effects of anti-tumor immunity in a tumor microenvironment
VGluT3-expressing CCK-positive basket cells construct invaginating synapses enriched with endocannabinoid signaling molecules in particular cortical and cortex-like amygdaloid regions of mouse brains
Is human intestinal spirochetosis associated with sessile serrated adenoma/ polyp?
Studies on the Development Process of Angiotensin II-Induced Skeletal Muscle Abnormalities and Role of NAD(P)H Oxidase 2
Functional analysis of Ceacam1 that is expressed in the glioblastoma-initiating cells
Influence of light exposure in night time on sleep development of preterm infants
Studies on regulatory mechanism of osteoclast development and bone resorption by Siglec-15
Studies on the usefulness of endoscopic papillary large balloon dilation for large bile duct stones
Novel Pharmacological Target for the Treatment of Ocular Neovascular Diseases
Studies on the role of ATG9 gene and autophagy in preeclampsia model mice
Studies on inhibitory interaction between graft-derived and reconstituted T cells involves murine chronic graft-versus-host disease
Postoperative assessment of donor's hepatic asialoglycoprotein receptor function using Tc-99m GSA scintigraphy in living donor liver transplantation
Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the chondrogenic differentiation independent of insulin
Short sleep duration and insomnia increase the risk of chronic kidney disease in Japanese workers
Induction of immunosuppressive macrophage-like cells from mouse iPS cells that contribute to prolong same iPS cells-derived graft survival in allogeneic recipients
A study of the chondroprotective effects of high molecular weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model
Role of Interleukin-17 in a Murine Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia Model.
Cell type-specific innate immune response to cytoplasmic viral DNA and its suppression by viral proteins
TRIM39 negatively regulates NFκB signal through stabilization of Cactin
Studies on biological properties and immunosuppressive function of myeloid-derived suppressor cells in tumor microenvironment
The analysis of effects of the combined epigenetic therapy with EZH2 and HDAC inhibitors on NSCLC cells
PolyI:C-induced necroptosis is TLR3/RIP3-dependent in mouse tumor cell lines
Anti-adipogenic and anti-viral effects of L-carnitine on hepatitis C virus infection
Studies on EMT-related molecules in intrahepatic cholangiocarcinoma.
Exercise capacity in chronic kidney disease
Changes in retinal layer thickness and choroidal blood flow velocity in multiple evanescent white dot syndrome
Studies on the use of thyroglobulin concentration in postmortem blood samples in forensic diagnosis
Studies on gene mutation profile of pancreatic cancer obtained using a single targeted deep sequencing assay and its utility as a prognostic biomarker
Strong cytoplasmic expression of NF-κB/p65 correlates with good prognosis in triple negative breast cancer
LMIR3/CD300f deficiency aggravates inflammatory bowel disease
Studies on the comparison of different symptom assessment scales for multiple system atrophy
Studies on mechanisms of invasion and metastasis in bladder cancer
TLR2 signal enhances survival and immune-suppressive activity of MDSCs
Small conductance Ca2+-activated K+ current is upregulated via the phosphorylation of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy
Studies on the causative genes and pathogenesis in two forms of palmoplantar keratodermas; Nagashima-type palmoplantar keratosis and striate palmoplantar keratoderma
Analysis of microRNAs in human synovial sarcoma
CD74 expression is increased with amplified activation of parietal epithelial cells by lipopolysaccharide treatment in the mouse model of focal segmental glomerulosclerosis
The SKINT1-like Gene Is Inactivated in Hominoids But Not in All Primate Species: Implications for the Origin of Dendritic Epidermal T Cells
Postnatal stress exposure infers depressive-like behavior and morphological changes in rats
New insight into the host and virus interaction of HBV