Surgery homepage

Renal and Genitourinary Surgery

  • Professor: Nobuo Shinohara
  • Associate Professor: Kimihiko Moriya
  • Assistant Professor: Daiki Iwami
  • Assistant Professor: Sachiyo Murai
  • Phone: +81-11-706-5966
  • FAX: +81-11-706-7853
  • E-mail: u-ikyoku
Department of Renal and Genitourinary surgery carry out clinical medicine, comprehensive surgical education to the medical students and young surgeons, and a strong foundation for basic research related to the field for post graduate students. In clinical fields, we pay much attention to pediatric urology, renal transplantation and renovascular surgery, voiding function, and urooncology. Recent advances in laparoscopic surgery have led us to minimally invasive approach of the surgery in various urological diseases. Organ and tissue sparing procedures have also been pursued for keeping postoperative QOL.

Research

Main topics of basic researches are as follows: 1) evaluation of brain activation during various bladder status with a positron emission tomography, 2) regeneration of central nervous system for lower urinary tract dysfunction, 3) immunological analysis of chemokine and cytokine in allograft renal transplantation, 4) molecular biological analysis of renal cell carcinoma and its vascular endothelial cells, 5) regulation of PSA in the prostate cancer by ubiquitination, 6) development of new imaging system to urologic cancer.
Main topics of clinical researches are as follows: 1) one-stage repair in hypospadias, 2) high-risk renal transplantation, 3) evaluation and treatment of lower urinary tract dysfunction and associated symptoms, 4) voiding analysis to the prostate cancer patients after radical prostatectomy and radiation therapy, 5) new treatment strategy against bone metastasis in kidney and prostate cancer patient, 6) neoadjuvant cytokine therapy for metastatic kidney cancer.
A sophisticated surgical training program and basic surgical research are fundamental to obtain the best clinical outcome. We believe that our goal is “ from bench to bedside ”.

Education

Our educational programs during medical school include the fundamental knowledge to understand the urological disease and the practical methods for diagnostic examination and treatment strategy. In the sixth grade students, practical training class has held to consider the actual problems in patients. The patients are assigned for studying diagnosis, medical and surgical treatment, and perioperative management with junior or senior resident.
Junior residents learn general urology and experience basic urological surgeries for 6 years. Thereafter, they become senior resident and learn fur-advanced urological works for 5 years. After the program completed, they obtain advanced urological opinion, higher tactics, and reliable technique. Also, they keep a research mind to further medical advancement.

International Activities

Recent presentations in international conference
  • Mitsui T (2007) European Association Urology Congress, Berlin, Germany.
  • Shinohara N (2007) ASCO meeting, Chicago, USA.
  • Miura M (2007) American Transplant Congress, San
    Francisco, USA.
  • Kitta T (2007) American Urological Association Annual
    Meeting, Anaheim, USA.
  • Kitta T (2007) International Continence Society, Rotterdam,
    Netherlands.
  • Osawa T (2007) Congress of the Societe Internationale
    d’Urologie, Paris, France
Fig1
Fig2 Fig3
Fig4
1 Members of Dept. Urology. with professor Nonomura, in the center of the front line.
2 View of the operation of urethroplasty.
3 Laparoscopic surgery is conducted for many cases.
4 Schematic illustration of a model for ubiquitylation of e-COP by PIRH2 in androgen receptor system.

Selected Publications

1. Moriya K, Kakizaki H, Tanaka H, Mitui T, Furuno T, Kitta T, Higashiyama H, Sano H, Nonomura K (2007) Long-term patient reported outcome of urinary symptoms after hypospadias surgery: norm related study in adolescents. J Urol 178: 1659-1662.
2. Abe T, Shinohara N, Harabayashi T, Sazawa A, Maruyama S, Suzuki S, Nonomura K (2007) Impact of multimodal treatment on survival in patients with metastatic urothelial cancer. Eur Urol. 52: 1106-1114.
3. Kitta T, Kakizaki H, Tanaka H, Sano H, Furuno T, Mitui T, Moriya K, Nonomura K (2007) An α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate glutamate-receptor antagonist can inhibit premicturition contractions in rats with bladder outlet obstruction. BJU international 100: 181-186.
4. Maruyama S, Miyajima N, Bohgaki M, Nonomura K, Hatakeyama S (2007) Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. Mol Cell Biochem 307: 73-82.
5. Shimoda N, Fukuzawa N, Nonomura K (2007) Cathepsin G is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Am J Patho 170: 930-940.