Reproductive and Developmental Medicine homepage


  • Professor: Tadashi Ariga
  • Lecturer: Masafumi Yamada
  • Assistant Professor: Kiyoshi Egawa
  • Phone: +81-11-706-5954
  • FAX: +81-11-706-7898
The mission of the Department of Pediatrics is to provide the highest quality clinical practice for prevention and treatment in a wide range of childhood disease, generating new knowledge through scientific research. Combination of clinical and research activities in the Department has developed highly recognized achievements including the first successful human gene therapy in Japan for ADA-SCID conducted in 1995. For the next generation of medical trainees, a large patient population in all over Hokkaido and experts in every field of pediatrics offer a superb educational opportunity, enabling them to pursue flourishing career as a pediatrician as well as a researcher.


The department has 10 research groups covering a wide range of pediatric disorders.
Immunology Group deals with immunodeficiency, allergy and collagen diseases. The group is renowned for the first successful human gene therapy in Japan.
Infectious Disease Group is well known for research in virology, including human metapneumovirus and human bocavirus.
Endocrinology Group is working on all aspects of pediatric endocrine disorders including growth problems, abnormal puberty, and diabetes mellitus.
Nephrology Group provides total care for patients with renal disorders including congenital anomalies, nephrotic syndrome, and renal failure.
Cardiology Group offers diagnosis and treatment for pediatric cardiac disorders including congenital heart disease, arrhythmia, and Kawasaki disease.
Hematology and Oncology Group functions as a center for diagnosis and treatment of patients with pediatric malignancy including leukemia/lymphoma and solid tumors, offering highly sophisticated blood stem cell transplantation.
Neurology Group takes care of patients with neurological disorders including developmental delay, epilepsy and muscular dystrophy. Neonatology Group offers intensive care for any problems of neonates including immature babies, congenital anomalies, and infection.
Medical Genetics and Dysmorphology Group offers diagnosis, management and genetic counseling for patients with genetic disorders.
Metabolic Disease Group deals with patients with congenital metabolic disorders and diseases in digestive system.


We provide the best education for medical students. Our education program for undergraduate students features systematic lectures and clinical clerkship. Specialists covering every field of pediatrics provide an excellent opportunity to recognize the wide spectrum of clinical pediatrics.
Graduate students can work on a wide variety of research activities. Combination of clinical and research opportunity would promise a successful career not only in pediatrics but in basic science.
We offer the integrated 3-year Residency Program. The goal of the program is to obtain the board certification of pediatrics. The Program is supported by a collaborative effort with the University Hospital and related institutions in Hokkaido. Under this program, the core of general pediatrics training will be provided through the extensive clinical experience in these institutions.
1 Stem cell gene therapy for ADA deficiency
2 Members of the department

International Activities

1. Ariga T: International Symposium: Gene Therapy Clinical Trials from Around the Globe, Hematopoietic stem cell gene therapy for two patients with adenosine deaminase (ADA) deficiency without myelopreparative conditioning; a suggestion for the optimal protocol for HSC gene therapy for ADA deficiency. The 10th Annual Meeting of American Society of Gene Therapy, Seattle (USA), 2007
2. Ariga T: Hematopoietic stem cell (HCS) gene therapy for two patients with adenosine deaminase (ADA) deficiency without cytoreductive conditioning; a suggestion for the optimal protocol for HSC gene therapy for ADA deficiency. Symposium VI Immune deficiency syndromes. The IVth Conference on Stem Cell Gene Therapy, Halkidiki, Thessaloniki, Greece, 2007
3. Shiraishi H: Graded magnetoencephalographic analysis for patients with epilepsy - For the global application for every patient with epilepsy -. Matsushima, Japan, 2007

Selected Publications

1. Kida M, Fujioka H, Kosaka Y, Hayashi K, Sakiyama Y and Ariga T: The first confirmed case with C3 deficiency caused by compound heterozygous mutations in the C3 gene; a new aspect of pathogenesis for C3 deficiency. Blood Cell Mol Dis 40: 410-413, 2008
2. Okuhara K, Abe S, Kondo T, Fujita K, Koda N, Mochizuki H, Fujieda K and Tajima T: Four Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism caused by DAX-1 gene mutations: mutant DAX-1 failed to repress steroidogenic acute regulatory protein (StAR) and luteinizing hormone beta-subunit gene promoter activity. Endocr J 55: 97-103, 2008
3. Ishikura K, Ikeda M, Hattori S, Yoshikawa N, Sasaki S, Iijima K, Nakanishi K, Yata N and Honda M: Effective and safe treatment with cyclosporine in nephrotic children: a prospective, randomized multicenter trial. Kidney Int 73, 1167: 2008
4. Asahina N, Shiga T, MD, Egawa K, Shiraishi H, Kohsaka S and Saitoh S : [11C]Flumazenil PET Analyses of Brain GABAA Receptors in Angelman Syndrome. J Pediatr 152: 546-549, 2008
5. Endo R, Ishiguro N, Kikuta H, Teramoto S, Shirkoohi R, Ma X, Ebihara T, Ishiko H and Ariga T: Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan. J Clin Microbiol 45: 3218-3223, 2007
6. Murakami T, Ueno M, Takeda A and Yakuwa S: Pressure wave reflection after successful balloon dilatation of aortic coarctation. Circ J 71: 1821-1822, 2007