Sensory Organ Medicine

Otolaryngology-Head and Neck Surgery

  • Professor: Hiroshi Shimizu*
  • Associate Professor: Akihiro Honma
  • Assistant Professor: Keishi Fujiwara
  • Phone: +81-11-706-5958
  • FAX: +81-11-717-7566
  • *concurrent
The Department of Otolaryngology Head and Neck Surgery at the Hokkaido University delivers high qualified services to patients and good education program to medical students and residents by the well trained specialists in following sub-specialized areas.
  • Multimodality therapy and oncology of head and neck cancer
  • Otology and neurotology
  • Ear surgery and cochlear implant
  • Treatment and rehabilitation of voice and swallowing
  • Immunology of allergic rhinitis and other auto immune diseases in the head and neck area
  • Computer-assisted nasal surgery and skull base surgery
  • Pathogenesis and virology of facial nerve diseases
We also focus on contribution to development of our field through research activities of basic science such as oncology, otology, neurotology, immunology, anatomy and pathology.


In a field of otology, we elucidated that the screening and detection of DNA for herpes simplex virus type I (HSV-1) and with varicella zoster virus (VZV) from the saliva of patients with facial nerve palsy is effective for early diagnosis and therapy of Bell's palsy and zoster sine herpete. In the future, we would try the clarification for the sudden deafness, which is still unknown etiology, in the similar molecular biological method. Furthermore, we have performed the basic research for distortion product OAE as a screening of infant healing loss, and for cochlear implant to severe deafness.
In a field of rhinology, the chief theme of our research is Wegener's granulomatosis. The relations between the disease and c-ANCA, p-ANCA or HLA (especially HLA-DR9) are under investigation. Additionally, we have studied the treatment method for the nasal localized form of Wegener's granulomatosis. The results showed that a nasal cleaning with a low dose corticosteroid or Sulfamethoxazole/Trimethoprim is effective to reduce an inflammation and to suppress a formation of the nasal crust.
In a field of head and neck carcinoma, we have developed the surgery to preserve a function at maxillary carcinoma and laryngeal carcinoma. Furthermore, we have performed a basic research for the chemoprevention of cancer, a molecular biological study for the mechanisms of the resistance to anticancer drugs, and an identification of a novel oncogene in the head and neck squamous cell carcinoma with the exhaustive methods.


The educational mission of the Otolaryngology training program at Hokkaido University is to prepare physicians to become competent and highly skilled otolaryngologists with excellent preparation in clinical and surgical patient care, mastery of existing knowledge within the scope of practice, and appropriate experience in teaching and research. In addition to medical knowledge and patient care in the above mentioned areas, the department teaches and evaluates performance in interpersonal and communication skills, professionalism, systems-based practice and practice-based learning. To this end, the program has established goals and objectives for each level of postgraduate year and a formative and summative evaluation process to measure progress along the way. In such an environment the developing otolaryngologist can reach his or her full potential by the completion of the program.
1 Computer-assisted navigation system in endoscopic sinus surgery
2 Video-assisted direct laryngoscopy performed by physicians
3 Superselective intra-arterial infusion of anticancer drug for advanced head and neck cancer

International Activities

There are presentations in the following international congress recently.
  • Fukuda S (2005) American Academy of Otolaryngology-Head and Neck surgery Foundation Annual Meeting. LA, USA
  • Oridate N (2008) 7th International Conference on Head & Neck Cancer. San Francisco, USA
  • Nakamaru Y (2008) International Conference of the American Thoracic Society. Toronto, Canada
  • Takeichi N (2007) AAO-HNS Annual Meeting & OTO EXPO. Washington DC, USA
  • Tsubuku T (2007) The 9th Japan-Taiwan Conference in Oto-Rhino-Laryngology, Head and Neck Surgery. Sendai, JAPAN
  • Hatakeyama M (2007) American Association for Cancer Research Annual Meeting. LA, USA
International collaboration research is positively done in our laboratory, and two members are researching in USA and one member is in UK now.

Selected Publications

1. Takeichi N, Kaneko CR, Fuchs AF (2007) Activity changes in monkey superior colliculus during saccade adaptation. J Neurophysiol 97: 4096-4107.
2. Oridate N, Takeda H, Yamamoto J, Asaka M, Mesuda Y, Nishizawa N, Mori M, Furuta Y, Fukuda S (2006) Helicobacter pylori seropositivity predicts outcomes of acid suppression therapy for larngopharyngeal reflux symptoms. Laryngoscope 116: 547-553.
3. Homma A, Furuta Y, Oridate N, Suzuki F, Higuchi E, Nishioka T, Shirato H, Nagahashi T, Yagi K, Fukuda S (2006) "Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy. Int J Clin Oncol 11: 441-448.
4. Tsubuku T, Akao T, Kurkin SA, Fukushima K (2006) Prediction in the timing of pursuit eye movement initiation revealed by cross-axis vestibuloar-pursuit training in monkeys. Exp Brain Res 168: 427-435.
5. Nakamaru Y, Oridate N, Nishihira J, Takagi D, Furuta Y, Fukuda S (2005) Macrophage migration inhibitory factor (MIF) contributes to the development of allergic rhinitis. Cytokine 31: 103-108.