Internal Medicine

Gastroenterology and Hepatology

  • Professor: Naoya Sakamoto
  • Associate Professor: Shunsuke Ohnishi
  • Assistant Professor: Koji Yamamoto
  • Assistant Professor: Kazumichi Kawakubo*
  • Phone: +81-11-716-1161
  • FAX: +81-11-706-7867
  • *concurrent
The Third Department of Internal Medicine was established in 1947 as the Third Internal Medicine Department in Hokkaido University School of Medicine. This department has been headed since 1994 by Professor Masahiro Asaka, the fourth professor of the department since its establishment, and more than 700 students have studied in this department. In 2000, the Third Department of Internal Medicine became the Gastroenterology and Hematology Section of the Department of Internal Medicine. Research and treatment in the fields of gastroenterology, hematology and clinical oncology have been carried out in this department. Currently, diagnosis and treatment of gastrointestinal cancer and latest treatments including bone marrow transplantation for patients with hematologic diseases are being carried out.


Significant progress has been made in research in various fields, including basic research on genetic diagnosis and gene therapy for hematopoietic organ tumors and malignant gastrointestinal tumors, research aimed at elucidation of the association between Helicobacter pylori infection and gastric diseases, molecular biological analysis of hepatic viruses and liver cancer, research aimed at the establishment of a method for culturing hematopoietic stem cells, and research aimed at the elucidation of graft rejection after bone marrow transplantation and the development of new treatments.


The goal of education for medical students is not only to provide students with basic knowledge and skills but also to produce doctors with good personal qualities.
Training after graduation is provided by experienced doctors in affiliated hospitals throughout Hokkaido in fields ranging from primary care to high-level care.

International Activities

Kondo T (2009) 14th Annual Meeting of the European Society of Hematology
Hige S (2009) 60th Annual Meeting of the American Association for the Study of Liver Diseases
Kato M (2009) GASTRO2009 UEGW/WCOG
Yamamoto K (2009) GASTRO2009 UEGW/WCOG
Nishida U (2009) GASTRO2009 UEGW/WCOG
Lab members

Selected Publications

1. Takeda H, Asaka M (2008) Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 134: 2004-13.
2. Fukase K, Kato M, Asaka M (2008) Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet 372: 392-7.
3. Higashi H, Asaka M (2002) SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295: 683-6.
4. Onozawa M, Hashino S, Asaka M (2005). Side effects and good effects from new chemotherapeutic agents. Case 2. Thalid omide-induced interstitial pneumonitis.
J Clin Oncol 23: 2425-6.
5. Ohkawara T, Takeda H, Asaka M (2002) Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Gastroenterology 123: 256-70.
6. Chuma M, Asaka M (2003) Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma.
Hepatology 37: 198-207.